The Broken Brain Podcast with Dr. Mahmoud Ghannoum and Afif Ghannoum

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Most people understand the importance of a healthy gut microbiome for overall health, but have you heard of the mycobiome—the fungi that live inside our bodies, and how it impacts our health?

On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Mahmoud Ghannoum and Afif Ghannoum. Dr. Mahmoud Ghannoum is a tenured professor and director of the Center for Medical Mycology at Case Western Reserve University and University Hospitals Cleveland Medical Center in Cleveland, Ohio. He has spent his entire career studying medically important fungi and publishing extensively about their virulence factors, especially in microbial biofilms. Dr. Ghannoum is the scientist that named the mycobiome, the fungal community in the body, and was dubbed “the scientist who is now known as the leading microbiome researcher in the world” by the Washington Post. He is also the founder of the leading antifungal clinical testing company in the world, Next Trillion Sciences, and has been involved in the development of 95% of the antifungals that have come to market since the 1990’s.

Afif Ghannoum is a biotechnology attorney by training. He has turned his biotechnology innovations into consumer products that have sold in over 27,000 retail locations in the United States. He has also licensed a technology to a global pharmaceutical company that is now sold in over 100,000 retail locations. Afif is currently the CEO of BIOHM Health, where he has commercialized consumer probiotics and microbiome testing kits around the dual role that fungi and bacteria play in the digestive tract.

In this episode, Dhru, Dr. Ghannoum, and Afif talk about the mycobiome and how it can directly influence our weight, digestion, immune system, and mood. They discuss how fungi work in the human gut, in ways that are beneficial, neutral, or detrimental to our health. They also talk about how it can take months or years to shift your gut bacteria in a significant way, but you can alter your gut fungi profile for better or for worse in just 24 hours by changing your diet. Dr. Ghannoum and Affi also explain how their product, BIOHM, helps to maintain the balance of bacteria and fungi in the gut, all while breaking down digestive plaque.

In this episode, we dive into:

  • The mycobiome and how it impacts our health (3:32)
  • What happens when our fungi get out of balance (7:25)
  • The damage antibiotics can cause when it comes to the mycobiome (12:31)
  • Biofilm and how it impacts the mycobiome (15:36)
  • How you can alter your gut fungi for better or worse in just 24 hours (25:19)
  • Foods that traditionally get a bad rap and how might they have a positive impact on our mycobiome (38:38)
  • What we should be eating to take care of our fungi community (45:13)
  • How sleep impacts our gut health (49:42)
  • How environmental factors positively or negatively impact the mycobiome (1:01:04)
  • How Dr. Ghannoum started his career (1:21:22)
  • Where to learn more about Dr. Ghannoum and Afif (1:30:11)

I know you’ll love this episode of The Broken Brain Podcast as much as I did.

For more on Dr. Mahmoud Ghannoum and Afif Ghannoum, be sure to follow them on Instagram @biohmhealth, @dr.microbiome, and @afifghannoum, as well as on Facebook @biohmhealth. Check out their website and You can find Dr. Ghannoum’s book, Total Gut Balance: Fix Your Mycobiome Fast for Complete Digestive Wellness, right here.


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